We are a team of programmers/mathematicians , which deals with calculations of microbial processes in order to improve their effectiveness.
The program is designed for engineers and scientists in the microbiological industry and R&D areas for planning, analysis and control of the fermentations, as well as for undergraduate and graduate students who are trained in the microbiological field.
An Integrated Mathematical Model of Development (IMMD) is the basis of these calculations. The IMMD have 3 basic paradigms.
Russian Federation Patent # 2228352:
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For biomass:
dnXdiv/d((Xst))n= {(K/A2) ∗ [(−1)(n−1)]*n!} / [(Xst)(n+1)]− C, (1);
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For product(substrates):
dP(or − S)/dτ = kdiv(for P and-S)Xdiv + kst(for P and -S)Xst, (2).
Please, see http://iopscience.iop.org/1758-5090/3/4/045006
- For each separate phase we must have separate equations.
The physiological processes occurring in proliferating and stable (non-proliferating) cells differ greatly and are diametrically opposed. We assume that metabolites are synthesized only by proliferating cells. Nonproliferating cells, as a rule, destroy these products. Therefore, signs of the constants for metabolite synthesis and degradation are opposite. The same should be stated for substrates utilized for cell construction.
Our equations describe all the known diversity of the processes with S-like growth curves and changes in the concentrations of substances in closed systems, which is an entirely new and previously unknown fact. It is known that a physical law means a generalization of a numerical relationship between the objects of the real physical world that is running under specified conditions for the class of the objects and does not follow from any of the previously discovered laws. There is no reason not to admit the two described equations for the GIP as laws for GIP.
The data obtained were used for the selection of techniques to increase the protein expression by genetically modified microorganisms.
Also, this software version allows you to calculate the energy indicators of the population:
- a - is a trophic factor;
- m - is specific an energy consumption for maintenance of life;
- f - is a consumption of an energy substrate for building of cells bodies.
This allows us to calculate the efficiency of the energy substrates consumption and, ultimately, the entire fermentation process.
