Chapter 9 Mathematical Modelling in Recombinant Plant Systems: The Challenge to Produce Heterologous Proteins Under GLP/GMP


In the last time and in the near future, the markets are demanding large recombinant proteins production capacity, due to the production levels of traditional platforms will be certainly not suffice to make available these demands (Huang and McDonald, Biotechnol Adv 30:398–409, 2012). The explore of alternative tools to assure adequate supplies for a growing demand constitutes a challenge of present times being the “bioengineered pharmaceutical plant” a promising strategy to respond to this require at affordable costs. However, as a commercial process requires high productivities and product yield at minimum cost, and, also, regulations must be follows like GMP and GLP. A mathematical model like the ones described in the present chapter allows making predictions and control of biosynthesis and yielding into the process.

Keywords: Mathematical modeling,  Recombinant proteins-Nicotiana tabacum-molecular, farming-cell suspension cultures

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